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- 09/03/25 - #470
09/03/25 - #470

Good morning. In today’s edition:
Researchers Tweaked Compound From Brown Seaweed That Appears to Hold Anti-obesity Potential – Not Through Appetite Suppression or Fat Burning, but by Targeting the Gut Microbiome to Fight Weight Gain Naturally and Long-term, Successfully Tested in Mice, Without Drugs or Diet Changes
New GLP-1 Pill for Weight Loss May Be Closer to Reality as Drugmaker Eli Lilly Says It Will File for Regulatory Approval
New Vaccine Shows Promise Against One of the Deadliest Cancers
Type 2 Diabetes Prevented With Adherence to Mediterranean Diet and Exercise, Study Finds
…and lots more. Have a great day!
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FOOD & NUTRITION
Researchers Tweaked Compound From Brown Seaweed That Appears to Hold Anti-obesity Potential – Not Through Appetite Suppression or Fat Burning, but by Targeting the Gut Microbiome to Fight Weight Gain Naturally and Long-term, Successfully Tested in Mice, Without Drugs or Diet Changes

A new study found that a natural compound from brown seaweed may help stop weight gain—without using drugs or going on a diet.
Scientists looked at fucoidan, a sugar found in seaweed like kombu, which is often eaten in Japan and Korea. Fucoidan is known to support the immune system and reduce inflammation. But in this study, researchers changed it to make it work better with gut bacteria.
They made four new versions of fucoidan and tested them on mice. The version called LMWF4 worked best. It had the smallest size and the most active ingredients. This helped it reach the gut and change the balance of bacteria.
Mice that ate a high-fat diet and took LMWF4 gained less weight, had lower blood sugar and cholesterol, and had more healthy gut bacteria. These bacteria, like Akkermansia and Blautia, are linked to better health and less body fat.
The compound did not cut hunger or burn fat. Instead, it helped the gut grow more “good” bacteria and reduce the “bad” ones tied to obesity and inflammation.
Even though the study was in mice, the results are exciting. They show that helping the gut may be a safe and natural way to fight weight gain. And since fucoidan comes from food people already eat, it may be used in supplements or health products in the future.
More research in humans is needed, but this may be a new way to support long-term weight and gut health.
WEIGHT LOSS
New GLP-1 Pill for Weight Loss May Be Closer to Reality as Drugmaker Eli Lilly Says It Will File for Regulatory Approval

A new weight-loss pill may soon hit the market. Drugmaker Eli Lilly says it now has the full data needed to ask for approval to sell its new pill, called orforglipron.
This pill is part of a group of drugs known as GLP-1s. These medicines help people lose weight and manage type 2 diabetes. They work by lowering blood sugar, helping you feel full longer, and reducing hunger. GLP-1s are already used in shots like Zepbound and Mounjaro, but not everyone likes needles. Pills are easier for many people to take.
In a recent trial, people who took the highest dose of the pill once a day lost about 23 pounds over 72 weeks. The pill also lowered A1C, a key blood sugar number, by an average of 1.8%.
Unlike another GLP-1 pill, Rybelsus, Lilly’s pill does not require strict food and water rules when taken. That could make it more convenient.
Side effects were similar to those seen with GLP-1 shots. Most people reported mild stomach upset.
Lilly is already making large batches of the pill and hopes it will be used not just for weight and blood sugar, but possibly for other conditions like high blood pressure or sleep apnea in the future.
Experts believe pills like this could become a good long-term option, especially for people who start with shots and later want something easier to manage.
Always talk to your doctor before starting any new medication.
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HEALTH
New Vaccine Shows Promise Against One of the Deadliest Cancers

A new vaccine may help people live longer after treatment for pancreatic cancer—one of the deadliest cancers. Early studies show the vaccine helps the immune system fight cancer cells.
Pancreatic cancer is hard to treat and often deadly. Only about 13 out of 100 people live five years after being diagnosed. But a small study gave hope. Sixteen patients had surgery and chemotherapy, then got a new mRNA vaccine called autogene cevumeran. Half of them showed a strong immune response. For those patients, the cancer was less likely to return after three years.
The study took place at Memorial Sloan Kettering Cancer Center. Dr. Vinod Balachandran, who led the trial, said the vaccine was safe and helped the body make cancer-fighting T cells. These cells may stop the cancer from coming back.
The vaccine is not a cure. But it may help people live longer with fewer relapses. It was made by BioNTech and Genentech, the companies that also helped make the Pfizer COVID-19 vaccine. A larger study is now being done to compare the vaccine with standard care.
Experts say this could be the start of new ways to treat other hard-to-fight cancers. More research is needed, but the results are promising.
If this new approach works in more people, it could give doctors a powerful new tool against one of the toughest cancers.
Disclaimer: This article is for informational purposes only and is not medical advice. Please talk to your doctor about your health.
Type 2 Diabetes Prevented With Adherence to Mediterranean Diet and Exercise, Study Finds

A new study shows that people ages 55 to 75 can lower their risk of type 2 diabetes by eating a Mediterranean diet, exercising daily, and getting support.
The study followed almost 7,000 people in Spain. All were overweight or obese and had signs of poor health, like high blood sugar and belly fat. Half the group followed a lower-calorie Mediterranean diet and walked 45 minutes a day, six days a week. They also met with diet coaches. After six years, this group had a 31% lower chance of getting type 2 diabetes.
The Mediterranean diet includes fruits, vegetables, whole grains, beans, and healthy fats like olive oil. It limits sugar, white bread, butter, and red meat. The diet also encourages oily fish and small portions of poultry, eggs, and dairy.
Even small weight loss helped. People lost just 3–4% of their weight, but they also lost belly fat and gained muscle. Experts say this change in body shape helped lower diabetes risk.
One key to success was support. The group met with dietitians, set goals, and tracked their habits. That helped them stick to the plan for years.
The other group got basic advice but no support, exercise plan, or calorie limits. They did not see the same health results.
The takeaway: Eating better, moving more, and getting regular support may help prevent type 2 diabetes — even later in life.
This article is for information only and not medical advice.
✢ A Note From Hem Hero
The information in this health newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment; always consult your healthcare provider with any questions or concerns you may have regarding your health. The publishers are not responsible for any actions taken by the reader based on the information provided.